Neurotech Notables #56: June 1-15, 2026

Valuation Nation + Oakland Happy Hour 6/25🍸

Hi Readers,

In the last two weeks: SpaceX had the biggest-ever IPO, raising $85.7B for a $2T valuation, OpenAI ($852B post-money) and Anthropic ( $965B post-money) both announced their IPO plans, and the latter was served an export control on their latest model.

From outer space to inner space, Neurotech is part of this too. Buckle up.

• Bezos led a $500m investment in Flourish, a new neuroAI company led by CTRL-Labs founder Thomas Reardon. Per Wired, Flourish will build new algorithms and chips for faster learning at a reported $2.5b valuation, which puts it alongside reported valuations of Science Corp’s $1.5b, Synchron’s ~$1b, and Merge Labs’ $850m. But below Neuralink’s $9b.

• Intel Inside? Intel announced a new strategic partnership with Edward Chang’s stealth BCI Startup, Echo Neurotechnologies to “develop algorithms that are not just brain-inspired, but actually trained on brain activity itself. This will allow us to build highly energy-efficient computing architectures and platforms that are faster, lighter and closer to how humans actually think.”

• Big Chip: A new report from Korea revealed Samsung’s R&D contract to build’s Neuralink fourth-gen chips. They shipped first test chips last month, with full production scheduled for 2027. The deal follows Neuralink’s president DJ Seo’s visit to South Korea last year, and runs in parallel to SpaceX’s $55m bet on Terafab, a new AI chip plant project in Texas.

• Meanwhile, outside the BCI-AI realm: Medtronic posted a $2.75b quarter in Neuro (at a $123b company valuation), Nyxoah priced a $95m IPO, GT Medical raised $100m for implantable brain cancer treatment, along with CereVasc’s $95m for Hydrocephalus.

• Wave secured a big FDA clearance for their PTSD TMS protocol. Setpoint launched a post-market registry. Paradromics just announced their FIH. Neuronoff enrolled their first patient in a DOD trial. Shiratronics completed enrollment for their Migraine Pivotal study and bagged new CPT codes. EpiWatch’s phase III trial. NRx and Emobot publish new data. New leaders at Neuraworx and WyssGeneva, and Robeauté partners with Google’s robotics accelerator.

• Brainy Day: Several new programs from ARPA-H, NSF, Allen Institute, as well as new brain health reports and partnerships in primary care, AI, and the global Brain Economy movement. New fund announcements.

• Plus: Cognitive testing news from Linus & Altoida. Pelara and Openwater bring focused ultrasound to pets. Cognision’s Ketamine EEG study. Many smart pieces and neat studies in TMS, tDCS, and more. New neuropixel opto probes. A shelf’s worth of new DBS studies.

And a cool new paper from Sergey Staviksy’s lab about a BCI user in Oakland. Speaking of Oakland: Join me for a drink next Thursday!

More (much more) coming to your inbox this summer, stay tuned.

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👋🏽 Hi, I’m Naveen. I believe brain health is human health. You are one of the 4,908 readers of my biweekly reports on emerging neurotech markets.
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Interested in Becoming an Ecosystem Partner? Inquire today.

• PL Neuro: Roadmap 2 - Expanding Neurotechnology to Consumer Products (Zenodo | Sean Escola)

• Resonant Link Medical: Implants are becoming more intelligent and companies like Resonant Link Medical are key to unlocking advanced capabilities without tradeoffs like limited data, increased size, or a compromised patient experience. Learn more here

• NANS: Development of an Educational Curriculum for the Surgical Implantation of DBS Systems- Read More

• TTP: What’s LEGO got to do with problem-solving? How LEGO Serious Play can help unstuck tough MedTech challenges - Discover more

• Datwyler: Recent work from EssilorLuxottica and Politecnico di Milano demonstrating Softpulse® dry electrodes integrated into smart glasses for EEG/EOG sensing and key challenges such as head-shape variability for scalable consumer device on signal quality - Learn More

• BrainMind: “Responsible innovation can not live in documents. It has to live in decisions.” - Diana Saville, Cofounder & President at BrainMind - Watch Asilomar summary here

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Funding

• Bezos leads $500 million in funding for Flourish to Fund a Wild Hunt for the Brain’s ‘Core Algorithm’ (Wired)

• GT Medical Technologies Completes Oversubscribed $100 Million Series E Equity Financing to Advance Commercial Treatment for Patients with Operable Brain Tumors (PR Newswire)

• Nyxoah Announces Proposed Offering of Ordinary Shares, prices $95m IPO (Biospace | Mass Device)

• CereVasc, Inc. Announces Over-Subscribed $85 Million Series C Financing to Advance its Novel eShunt® System for the Treatment of Normal Pressure Hydrocephalus (PR Newswire)

• General Neuro joins HAX/SOSV accelerator with pre-seed funding (General Neuro)

• ARPA-H launches Restorative & health-Enhancing Sleep Time, (REST) a program to redefine sleep as a measurable, controllable driver of health (ARPA-H)

• BRAINS Exploratory Topic: Regrowing Damaged Brain Regions to Restore Lost Function (ARPA H - Register for a live Q&A session and sidebars on June 24-25. Learn more and submit a solution summary by July 9.

• Lt. Gov Dan Patrick touts $3B DPRIT passage at Texas Brain Economy Summit (Houston Business Journal)

• Star51 Capital Announces First Close of Medtech Venture Fund (PR Newswire)

• U.S. National Science Foundation announces X-Labs Initiative, Tech Accelerators Initiative

• The Allen Institute launches the Brain Health Accelerator (Linkedin | Endpoints)

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Commercial

• Medtronic reports fourth quarter and full year fiscal 2026 results; delivers highest annual revenue growth in 10 years (PR Newswire)

  • Neuroscience Portfolio revenue of $2.751 billion increased 5.0% reported and 3.0% organic, with low-single digit increase in Neuromodulation, Cranial & Spinal Technologies, and Specialty Therapies, all on an organic basis.

  • Also: Medtronic completed acquisition of Scientia Vascular, “seamlessly integrating access and therapeutic portfolios for neurovascular care”

  • Signals #7: Will Medtronic’s $650m SPR Acquisition Reshape the Pain Market for Neuromod?

• ShiraTronics Completes Enrollment in Pivotal Trial for Chronic Migraine & Announces Acceptance of Five Category III CPT Codes (PR Newswire)

• Nexalin Technology Announces Issuance of U.S. Patent Covering Dynamic Frequency Stimulation for Anxiety, Depression and Insomnia (Nexalin)

• Kariya and NeuraLight Partner to Measure How Next-Generation GLP-1 Therapies Impact the Brain (Business Wire)

  • NeuraLight Biomarkers Reveal What Parkinson’s Gold-Standard Measurement Scale Misses in a Study Led by the Scale’s Own Developers (Business Wire)

• Resmed Completes Acquisition of Noctrix Health, Expanding Clinical Sleep Health Portfolio (Globe Newswire)

• NRx Pharmaceuticals (Nasdaq: NRXP) Strategic Partner Emobot Presents Late-Breaking Clinical Validation of the EMOCARE Depression Thermometer at ASCP 2026 (NRx Pharma)

• Nicole Soliday joins Neuraworx Medical Technologies as Vice President of Clinical and Regulatory (LinkedIn)

• Sychedelic tDCS headphones surpass crowdfunding goal, prepare for global launch (Kickstarter)

• West Health Joins Metis, Kicking off Brain Health Systems Transformation Effort (West Health)

• Robeauté has joined Google DeepMind’s first robotics accelerator (Linkedin)

  • And, peep the French microbot’s brand refresh. C’est magnifique.

• Hinge Health launches comprehensive Migraine Care Program (HingeHealth)

• Introducing Kyma Neuro’s Wearable BCI (Kyma Neuro)

• WyssGeneva announces Dr. Tracy Laabs as the new Director (Linkedin)

• Intel Corporation partners with Echo Neurotechnologies to develop algorithms that are trained on brain data (Linkedin)

• Samsung said to be making next-generation Neuralink brain chip (SAM Mobile)

  • If this reporting is true: “According to a report from Hankyung, Samsung Foundry has begun research and development on Neuralink’s fourth-generation chip. This marks the first time Samsung has secured a contract from Neuralink. The project reportedly carries the internal codename ‘O1’ and is expected to be manufactured using Samsung Foundry’s 4nm process technology. The chip is designed for use in Neuralink’s brain-computer interface systems. Samsung reportedly began work on the new chip late last year, and production of the first test chips started last month. The chip is scheduled to be shipped in the first half of 2027. If testing goes as planned, mass production could begin in the second half of next year.”

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Regulatory

We’re Seeking Policy and Regulatory Experts to contribute to our monthly Regulatory Digest, On The Reg. Just Hit Reply!

• Wave Neuroscience Announces FDA Clearance of MeRT® for PTSD (PR Newswire | Frontier Psychiatrists)

• Newmanbrain announces EU MDR Certification for fNIRS based assessment for mild cognitive impairment (LinkedIn)

• Setpoint launches post-market registry (Linkedin)

• ABILITY Neurotech receives approval to start clinical trial (StartupTicker)

• Datasea Intelligent Technology Ltd. Announces Advancement of Compliance Work and Related Procedures for U.S. FDA Establishment Registration and Device Listing for Its Acoustic Brain-Computer Interface Product (MorningStar)

• OIG: Feds may have overpaid MA plans by millions due to unsupported stroke diagnoses (Fierce Healthcare)

• The OMB and the Politicization of Science (NEJM)

• Tiny HHS office tasked with protecting research participants’ safety is running on fumes (STAT)

  • “OHRP’s division of education, which was small to begin with, lost all of its subject matter experts to RIFs or early retirements. Previously, it held annual workshops on new topics in research ethics such as psychedelics and AI, which typically drew more than 1,000 participants, according to former employees. In 2025, the office was hoping to tackle neuroethics — questions of sentience in brain organoids and considerations for recipients of brain-computer interfaces. That event never happened.”

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📌Community Board

🆕Pin your news - Highlight key deals, events, roles, or announcements!

• June 25th: East Bay Neurotech Happy Hour! In town for Deep Tech Week? join us for drinks in Oakland next Thurs night! Spread the word… luma.com/t73sswkl

• Will you join me this fall at Mount Sinai’s NYBCI Symposium Nov 4-6? Speaker proposals open until July 31: https://bit.ly/NYBCI26-cfp

• Chippin’ Away at Spinal Cord Injury - Thu, August 27, 2026 — 6:00 PM EST (Ian Burkhart Foundation)

• Calling Founders: Arkane Capital seek seed-stage startups with novel, non-invasive neuromodulation that can replace drugs and invasive modalities. If this describes you: Please reply with pertinent materials.

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Industry

Did you catch our BCI Hiring Map earlier this month? Check it out here.

• Working in BCI: Culture, Purpose, & Vision- Read More

• Paradromics completes first-in-human implant (Email Correspondence)

• Cognision Publishes Landmark Study Showing Ketamine Produces Opposite Brain Effects in Different Patients -- and That Outcome Can Be Predicted Using EEG (PR Newswire

• Overcoming the diagnostic gap in mild cognitive impairment in Parkinson’s disease: a pilot study employing a machine learning-/augmented reality-based digital biomarker (Altoida)

• Linus Health Digital Cognitive Assessments Meet or Surpass New CEOi Benchmarks for Early Cognitive Impairment Detection (PR Newswire)

• Accelerated TMS Reduces Teen Depression and Anxiety, New Case Study Finds (PR Newswire)

• Overcoming the diagnostic gap in mild cognitive impairment in Parkinson’s disease: a pilot study employing a machine learning-/augmented reality-based digital biomarker (Altoida)

• Vielight: A multimodal evaluation of transcranial photobiomodulation in mild cognitive impairment: Cognitive, metabolic, and neuroimaging outcomes of a pilot randomized controlled trial (Journal of Alzheimer’s Disease)

  • NCT05563298: Does this actually discern mitochondrial respiration? “Serum pyruvate and lactate increased with a reduced lactate-to-pyruvate (L/P) ratio (p = 0.007, d = -1.37). DMN FC increased (p = 0.014, d = 1.25), and plasma IL-6 declined (p = 0.02, r = -0.52).”

• Theranica Advances Nerivio® as a Transformative Therapy for Personalized Migraine Care (PR Newswire)

• Clinical trial seeks to advance intuitive assistive robotics for people with paralysis (PR Newswire)

• Brain Canada Fuels Major Brain Research Platforms in Montréal (PR Newswire)

• TMS Found to Improve Cognition in Addition to Treating Depression, New Study Finds (PR Newswire)

• Pelara Launches Its First U.S. Veterinary Clinical Trials of Low-Intensity Focused Ultrasound with OpenWater & SecureDX (EIN Presswire)

• Neuronoff Implants First Patient in DOD-Funded Trial of Injectrode® for Neurogenic Bladder in Spinal Cord Injury (PR Newswire)

• Measuring what matters in common mental health disorders with a digital measures set (Datacc | Linkedin)

• Neuropixels Opto sheds new light into deepest regions of the brain (Allen Institute)

• Building AI Neuroscience: From Atoms to Bits. Neuroscience is slow. How can we make it faster? (Amaranth Foundation)

• How Psychiatry Finally Found the Brain (David Carreon)

• Brain Implants are Unlocking a New Human-Machine Reality (Bloomberg)

• DUST presents an AMA with Karen Konkoly & Daniel Morris (Reddit)

• Building for Brain Health: tools which help prevent, diagnose, and ultimately treat cognitive decline (Linkedin)

• UWF professor receives U.S. patent for early Alzheimer’s detection technology (University of West Florida)

• Phase III Trial of EpiWatch for Tonic-Clonic Seizure Detection in Children and Adults (Neurology Journals)

• The New Frontiers for Young Minds Brain Prize Collection (Linkedin)

• When SSRIs fail: the neuromodulation pathway (Medical Device)

• 2026 Merkin Prize in Biomedical Technology awarded to pioneers of the modern cochlear implant (PR Newswire)

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Neurotech.TV

• Jacques Carolan — The Mission to Get Breakthrough Brain Treatments to Everyone (Juan Benet Podcast)

• Why Neurotech is the “Great Equaliser” for Brain Health | Dr Jason Mellad | Inside NeuroTech (Youtube)

• Episode 13: Can Neurotech Cure Epilepsy? with Mayo Clinic Neurosurgeon Dr. Jonathon Parker (Youtube)

• Inside a Brain-Chip Startup in China | Bloomberg Primer (Youtube)

• Video games show promise in stroke recovery (WGN9)

• Transforming Pain into Innovation: Ashwin Revolutionizes Neurological Care Now! (Youtube)

• TMS Works. Almost Nobody Gets It. Scott West, MD on Closing the Gap (Osmind)

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New Jobs from: Stealth Startup (!) Boston Scientific, Science COrp, CIONIC, CoMind, Synchron, Axo, Precision, Medpace, Neuralink, Soma Health, NeuroHarmonics, Harnham, Subsense, and more!

Job board 2.0 is coming this summer! What do you want to see? Hit Reply.

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Society

• Harris Eyre: AI use and the Brain (Linkedin)

• Nature Medicine and Global Brain Economy Initiative Launch Commission on Brain Health for Economic Resilience (EIN Presswire)

• Houston ranked as ‘brain-positive’ city with room to improve, Center for Houston’s Future says (Biz Journals)

• Primary care, reimagined: Workforce and care model innovation in a modern age (McKinsey)

• Bumblebees have tiny brains but they can solve problems like chimps and elephants (NPR)

• How Does One Brain Speak Two Languages? (NYTimes)

• Can Shocking Your Vagus Nerve Really Improve Your Health? (Nytimes)

Research

• Long-term independent use of an intracortical brain–computer interface for speech and cursor control (Nature Medicine | Nature)

• Adaptive deep brain stimulation for dynamic gait control in Parkinson’s disease: a randomized feasibility trial (Nature Medicine)

• Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease (Nature Medicine)

• Pre-stimulus brain states predict and control variability in stimulation responses (Brain Stimulation) (related patents)

• Distributed control circuits across a brain-and-cord connectome (Nature)

• Social intelligence Arises Between Minds (Psychology Today)

• Deep Brain Stimulation Remodels Brain Wiring and Alters Functional Changes to Brain-Wide Networks, Landmark Depression Study Reveals (Mount Sinai)

• Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks (Nature)

• Microglia in human models of development and disease: are we prioritising model ’success’ over biological truth? (IBRO)

• Transcranial direct current stimulation with motor-learning based gait therapy post-stroke: A randomized controlled trial (Brain Stimulation)

  • “In a RCT of 2mA bihemispheric tDCS paired with gait therapy in chronic stroke, no added benefit of tDCS was observed.”

• Wearable Myoelectric Interface for Neurorehabilitation (MINT) to Recover Arm Activity After Stroke: A Randomized Controlled Trial (Neurorehabilitation & Neural Repair)

• A new era in neurology (The Lancet)

• EEG-Controlled Exoskeleton for Walking and Standing: A Longitudinal Multimodal Dataset of Healthy Individuals (Nature)

• Real-world evidence of SAINT® effectiveness in a heterogenous clinical population with psychiatric and medical comorbidities: A multicenter, open-label, community-based study (Science Direct)

• Development of a human iPSC-derived corticospinal tract-on-a-chip (cell)

• Towards A Foundation Model for Clinical Voice Biomarkers (medRxiv)

• Clinical evaluation of communication brain computer interfaces in amyotrophic lateral sclerosis: a landscape analysis (Frontiers)

  • Excellent report!

• Researchers use ultrasound to create light inside the body (Stanford Report)

• Integrating neuroscience across species and scales (Nature Neuroscience)

• Real-time reinforcement for human-machine interface control (Neuron)

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That’s a wrap! What did we miss? Let me know for next time.
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